[CAS NO. ] (3S,4S)-A2-32-01

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PRODUCTS SPECIFICATIONS

Catalog

HY-111532B

Brand

MCE

CAS

-

DESCRIPTION

Overview

MDL	-
Molecular Weight	301.42
Molecular Formula	C19H27NO2
SMILES	O=C1O[C@@H](CCC2=CC=CN=C2)[C@@H]1CCCCCCCC=C

For research use only. We do not sell to patients.

Summary

(3S,4S)-A2-32-01 (compound 24(S,S)), a less active (S,S)-enantiomer of A2-32-01. A2-32-01 is a potent caseinolytic protein proteases (ClpP) inhibitor ^[1] .

Appearance

Oil

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 12.5 mg/mL ( 41.47 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3176 mL	16.5882 mL	33.1763 mL
5 mM	0.6635 mL	3.3176 mL	6.6353 mL
10 mM	0.3318 mL	1.6588 mL	3.3176 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 1.25 mg/mL (4.15 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1.25 mg/mL (4.15 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1.25 mg/mL (4.15 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Malte Gersch, et al. The mechanism of caseinolytic protease (ClpP) inhibition. Angew Chem Int Ed Engl. 2013 Mar 4;52(10):3009-14.