[CAS NO. ] Mant-GTPγS triammonium

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS

Catalog

HY-115748A

Brand

MCE

CAS

DESCRIPTION

Overview

MDL	-
Molecular Weight	723.48
Molecular Formula	C18H32N9O14P3S
SMILES	O=C(C1=C(C=CC=C1)NC)O[C@H]2[C@](O[C@@H]([C@H]2O)COP(OP(OP(O)(S)=O)(O)=O)(O)=O)([H])N3C4=C(C(N=C(N4)N)=O)N=C3.N.N.N

For research use only. We do not sell to patients.

Summary

Mant-GTPγS triammonium, a GTP mimetic, is a potent competitive adenylyl cyclase (AC) inhibitor. Mant-GTPγS triammonium is a potent YdeH inhibitor ^[1] ^[2] ^[3] .

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] Andreas Gille, et al. 2'(3')-O-(N-methylanthraniloyl)-substituted GTP analogs: a novel class of potent competitive adenylyl cyclase inhibitors. J Biol Chem. 2003 Apr 11;278(15):12672-9.
[2] Tomoharu Kanie, et al. The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base. Dev Cell. 2017 Jul 10;42(1):22-36.e12.
[3] Christian Spangler, et al. Interaction of the diguanylate cyclase YdeH of Escherichia coli with 2',(3')-substituted purine and pyrimidine nucleotides. J Pharmacol Exp Ther. 2011 Jan;336(1):234-41.