[CAS NO. 1338575-28-2] WWL229

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PRODUCTS SPECIFICATIONS [1338575-28-2]

Catalog

HY-120602

Brand

MCE

CAS

1338575-28-2

DESCRIPTION [1338575-28-2]

Overview

MDL	-
Molecular Weight	322.36
Molecular Formula	C16H22N2O5
SMILES	O=C(N1CCCCC1CCCOC)OC2=CC=C(C=C2)[N+]([O-])=O

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Summary

WWL229 is a selective inhibitor of carboxylesterase 3 (Ces3) with an IC ₅₀ of 1.94 µM. WWL229 promotes lipid storage in cultured adipocytes and prevents basal lipolysis ^[1] .

Appearance

Liquid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 775.53 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1021 mL	15.5106 mL	31.0212 mL
5 mM	0.6204 mL	3.1021 mL	6.2042 mL
10 mM	0.3102 mL	1.5511 mL	3.1021 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (6.45 mM); Clear solution

* All of the co-solvents are available by MedChemExpress (MCE).

References

[1] Dominguez E, et al. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. Nat Chem Biol. 2014 Feb;10(2):113-21.