[CAS NO. 2704602-92-4] PROTACBRD4Degrader-5-CO-PEG3-N3

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [2704602-92-4]

Catalog

HY-133736

Brand

MCE

CAS

2704602-92-4

MDL	-
Molecular Weight	1231.87
Molecular Formula	C58H75ClN12O12S2
SMILES	O=C(O[C@H]1CN(C([C@H](C(C)(C)C)NC(COCCOCCOCCNC(C[C@H]2C3=NN=C(C)N3C4=C(C(C)=C(C)S4)C(C5=CC=C(Cl)C=C5)=N2)=O)=O)=O)[C@H](C(N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)C1)COCCOCCOCCN=[N+]=[N-]

For research use only. We do not sell to patients.

PROTAC BRD4 Degrader-5-CO-PEG3-N3 (Compound 2) is a PROTAC-linker Conjugate for PAC, comprises the BRD4 degrader GNE-987 and PEG-based linker ^[1] .

Solid

Room temperature in continental US; may vary elsewhere.

In Vitro:

DMSO : 20 mg/mL ( 16.24 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 75 mg/mL (60.88 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 7.5 mg/mL (6.09 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2 mg/mL (1.62 mM); Clear solution

* All of the co-solvents are available by MCE.