[CAS NO. ] (-)SHIN2

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PRODUCTS SPECIFICATIONS

Catalog

HY-134978B

Brand

MCE

CAS

-

DESCRIPTION

Overview

MDL	-
Molecular Weight	406.48
Molecular Formula	C23H26N4O3
SMILES	N#CC([C@]1(C2=CC(C#CCCCO)=CC(CO)=C2)C(C)C)=C(N)OC3=C1C(C)=NN3

For research use only. We do not sell to patients.

Summary

(-)SHIN2 is the isomer of (+)SHIN2 (HY-134978A). (+)SHIN2 is an inhibitor of serine hydroxymethyltransferase (SHMT) with antileukemic effect. (+)SHIN2 synergisty with and Methotrexate (HY-14519) in vivo xenotransplantation models ^[1] .

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References

[1] García-Cañaveras JC, et al. SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia. Leukemia. 2021 Feb;35(2):377-388.