[CAS NO. 100648-13-3] Triclabendazole sulfoxide

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PRODUCTS SPECIFICATIONS [100648-13-3]

Catalog

HY-136450

Brand

MCE

CAS

100648-13-3

DESCRIPTION [100648-13-3]

Overview

MDL	-
Molecular Weight	375.66
Molecular Formula	C14H9Cl3N2O2S
SMILES	O=S(C1=NC2=CC(OC3=CC=CC(Cl)=C3Cl)=C(Cl)C=C2N1)C

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Summary

Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP ^[1] ^[2] .

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Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] Barrera B, et, al. The anthelmintic triclabendazole and its metabolites inhibit the membrane transporter ABCG2/BCRP. Antimicrob Agents Chemother. 2012 Jul;56(7):3535-43.
[2] Robinson MW, et, al. The comparative metabolism of triclabendazole sulphoxide by triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica. Parasitol Res. 2004 Feb;92(3):205-10.