[CAS NO. ] SM-433hydrochloride

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PRODUCTS SPECIFICATIONS

Catalog

HY-138059A

Brand

MCE

CAS

-

DESCRIPTION

Overview

MDL	-
Molecular Weight	598.18
Molecular Formula	C32H44ClN5O4
SMILES	O=C([C@@H]1CC[C@@](CCN(C(CC(C)C)=O)C[C@@H]2NC([C@@H](NC)C)=O)([H])N1C2=O)NCC3=CC=CC=C3C4=CC=CC=C4.Cl

For research use only. We do not sell to patients.

Summary

SM-433 hydrochlorid, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs) . SM-433 hydrochlorid exhibits strong binding affinity XIAP BIR3 protein with an IC ₅₀ <1 μM (patent WO2008128171A2) ^[1] .

In Vitro

SM-433 hydrochlorid exhibits strong inhibitory activity against MDA-MB -2131 human breast cancer cells and SK-OV-3 ovarian cancer cells (IC ₅₀ s<10 μM, respectively) ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 180 mg/mL ( 300.91 mM ; Need ultrasonic)

H ₂ O : 25 mg/mL ( 41.79 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6717 mL	8.3587 mL	16.7174 mL
5 mM	0.3343 mL	1.6717 mL	3.3435 mL
10 mM	0.1672 mL	0.8359 mL	1.6717 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 4.5 mg/mL (7.52 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 4.5 mg/mL (7.52 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 4.5 mg/mL (7.52 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Shaomeng Wang, et al. Diazo bicyclic smac mimetics and the uses thereof. WO2008128171A2.