[CAS NO. 3007772-60-0] ABD957
PRODUCTS SPECIFICATIONS [3007772-60-0]
DESCRIPTION [3007772-60-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 627.68 |
| Molecular Formula | C27H36F3N7O5S |
| SMILES | C[C@H]1CN(CCN1C(N2C=CC(S(=O)(N(C)C)=O)=N2)=O)CC3=C(C=C(C=C3)C(F)(F)F)N4C5CCC4CN(C5)CC(O)=O |
Summary
ABD957 is a potent and selective covalent inhibitor of the ABHD17 family of depalmitoylases, with an IC 50 of 0.21 µM for ABHD17B . ABD957 can block N-Ras signaling and the growth of NRAS-mutant AML cells [1] .
IC50 & Target
IC50: 0.21 µM (ABHD17B) [1]
In Vitro
ABD957 (500 nM; pretreated for 1 h) attenuates N-Ras depalmitoylation in AML cells
[1]
.
ABD957 (0.11 nM-10 μM; 72 h) blocks the signaling and proliferation of NRAS-mutant leukemia cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay [1]
| Cell Line: | OCI-AML3, THP1, HL60, NB-4 and NOMO1 cells |
| Concentration: | 0.1, 1, 10, 100, 1000, 10000 nM |
| Incubation Time: | 72 hours |
| Result: | Reduced the growth of NRAS-mutant AML cell lines (OCI-AML3, THP1 and HL60), but not KRAS mutant cell lines (NB-4 and NOMO1). |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 25 mg/mL ( 39.83 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.5932 mL | 7.9658 mL | 15.9317 mL |
| 5 mM | 0.3186 mL | 1.5932 mL | 3.1863 mL |
| 10 mM | 0.1593 mL | 0.7966 mL | 1.5932 mL |