[CAS NO. 2988135-14-2] FABPsligand6
PRODUCTS SPECIFICATIONS [2988135-14-2]
DESCRIPTION [2988135-14-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 458.52 |
| Molecular Formula | C28H27FN2O3 |
| SMILES | CC(C)C1=CC=C(N2C(C3=CC=CC=C3)=CC(C4=C(OCCCC(O)=O)C=CC(F)=C4)=N2)C=C1 |
Summary
FABPs ligand 6 (MF6) is an FABP5 and FABP7 inhibitor with K D values of 874 nM and 20 nM, respectively. FABPs ligand 6 can be used for multiple sclerosis research [1] .
IC50 & Target
K D : 20 nM (FABP7), 874 nM (FABP5) [1]
In Vitro
FABPs ligand 6 (MF6) rescues mitochondrial function by blocking voltagedependent anion channel (VDAC)-1-dependent mitochondrial macropore formation induced by psychosine in KG-1C cells, a FABP5- mediated injury [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MF 6 (1 mg/kg; i.g.; daily for 4 weeks) improves the severity of EAE (experimental autoimmune encephalomyelitis) and attenuates oxidative levels and the inflammatory response [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | 8-10-week-old female C57BMF/6J mice with MOG 35-55 -administered experimental autoimmune encephalomyelitis (EAE) mouse model [1] |
| Dosage: | 1 mg/kg |
| Administration: | Intragastric administration, daily for 4 weeks |
| Result: | Attenuated EAE symptoms, decreased oxidative stress, inhibited astrocyte activation and protected oligodendrocytes. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 125 mg/mL ( 272.62 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1809 mL | 10.9046 mL | 21.8093 mL |
| 5 mM | 0.4362 mL | 2.1809 mL | 4.3619 mL |
| 10 mM | 0.2181 mL | 1.0905 mL | 2.1809 mL |
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1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (4.54 mM); Clear solution