[CAS NO. 2927429-64-7] SphK2-IN-1

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PRODUCTS SPECIFICATIONS [2927429-64-7]

Catalog

HY-151350

Brand

MCE

CAS

2927429-64-7

DESCRIPTION [2927429-64-7]

Overview

MDL	-
Molecular Weight	518.92
Molecular Formula	C23H22ClF3N8O
SMILES	N=C(N1CCC[C@H]1C2=NC(C3=CC=C(C=C3)CN4C=C(N=N4)C5=CC=C(C=C5)C(F)(F)F)=NO2)N.Cl

For research use only. We do not sell to patients.

Summary

SphK2-IN-1 is a SphK2 inhibitor ( IC ₅₀ : 0.359 μM). SphK2-IN-1 can be used in the research of cancer , inflammation, neurological and cardiovascular disorders ^[1] .

IC50 & Target

SphK2

0.359 μM (IC ₅₀ )

In Vitro

SphK2-IN-1 (compound 25b, 125 µM, 24 h) inhibits cell viability against U-251 MG human glioblastoma cells ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay ^[1]

Cell Line:	U-251 MG human glioblastoma cells
Concentration:	125 µM
Incubation Time:	24 h
Result:	Decreased cell viability by more than 80%.

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References

[1] Vijai Kumar Reddy Tangadanchu, et al. Structure-activity relationship studies and bioactivity evaluation of 1,2,3-triazole containing analogues as a selective sphingosine kinase-2 inhibitors. Eur J Med Chem. 2020 Nov 15;206:112713.