[CAS NO. 3026893-31-9] AMPD2 inhibitor 2

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PRODUCTS SPECIFICATIONS [3026893-31-9]

Catalog

HY-152199

Brand

MCE

CAS

3026893-31-9

DESCRIPTION [3026893-31-9]

Overview

MDL	-
Molecular Weight	467.51
Molecular Formula	C26H27F2N3O3
SMILES	CC1(CN(C2=CC=C(C(F)=C2N1CC3=CC=C(C=C3)COC4=CC=C(C=C4)CO)F)C(N)=O)C

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Summary

AMPD2 inhibitor 2 (compound 21) is a potent AMP deaminase 2 (AMPD2) inhibitor with IC ₅₀ s of 0.1 μM and 0.28μM for hAMPD2 and mAMPD2, respectively. AMPD2 inhibitor 2 has the potential for evaluating the physiological role of AMPD2 in mice maintained on a high fat diet ^[1] .

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References

[1] Yuki Kitao, et al. The discovery of 3,3-dimethyl-1,2,3,4-tetrahydroquinoxaline-1-carboxamides as AMPD2 inhibitors with a novel mechanism of action. Bioorg Med Chem Lett. 2022 Dec 20;80:129110.