[CAS NO. 1174664-88-0] VER-00158411
PRODUCTS SPECIFICATIONS [1174664-88-0]
DESCRIPTION [1174664-88-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 538.64 |
| Molecular Formula | C31H34N6O3 |
| SMILES | O=C(C1=CN(CC2=CC=CC=C2)N=C1)NC(C=C3C(N4)=CC5=C4C=CC(OCC(C)(C)CN(C)C)=C5)=CNC3=O |
Summary
VER-00158411 is a checkpoint kinase 1 (CHK1) and CHK2 inhibitor with IC 50 values of 4.4 nM and 4.5 nM, respectively [1] .
IC50 & Target
|
Chk1 4.4 nM (IC 50 ) |
Chk2 4.5 nM (IC 50 ) |
In Vitro
Cellular sensing of DNA damage, along with concomitant cell cycle arrest, is mediated by a great many proteins and enzymes. One focus of pharmaceutical development has been the inhibition of DNA damage signaling, and checkpoint kinases (CHKs). There have been a number of clinical trial of checkpoint kinase inhibits alone or as a combination therapy for example, as a means to sensitize proliferating tumor cells to chemotherapies that damage DNA. The development of checkpoint kinase inhibitors the treatment of cancer was a major objective in drug discovery [1] .
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.