[CAS NO. ] Potassiumclavulanatecellulose

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PRODUCTS SPECIFICATIONS

Catalog

HY-19964

Brand

MCE

CAS

-

DESCRIPTION

Overview

MDL	-
Molecular Weight	238.26 (Potassiumclavulanate)
Molecular Formula	C8H9NO5K.(C6H10O5)n
SMILES	O[C@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](C)[C@@H](CO)O2)[C@@H](CO)O[C@@H](OC)[C@@H]1O.O=C([C@@H](/C(O[C@]3([H])C4)=C/CO)N3C4=O)O[K].[n]

For research use only. We do not sell to patients.

2 Publications Citing Use of MCE

Summary

Potassium clavulanate cellulose (Potassium clavulanate:cellulose (1:1)) is a mixture of potassium clavulanate and cellulose, is a bacterial β-lactamase inhibitor. Clavulanate potassium is a form of Clavulanic acid. Clavulanate potassium fights bacteria that resistant to penicillins and other antibiotics . Potassium clavulanate with the combination of amoxicillin can be used for the research of different infections caused by bacteria, such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and infections of the skin ^[1] ^[2] .

IC50 & Target

β-lactam

In Vitro

Clavulanate potassium (2 μg/mL) is susceptive to β-lactamase-positive and β-lactamase-negative Bacteroides spp. and Fusobacterium spp. with the combination of amoxicillin (4 μg/mL) and ticarcillin (64 μg/mL) ^[1] .
Clavulanate potassium (16 μg/mL) inhibits B. intermedius , B. bivius , B. disiens , B. oris , B. buccae , B. buccalis and B. loeschei with MIC ₅₀ values of 8 μg/mL ^[1] .
Clavulanate potassium (16 μg/mL) inhibits B. melaninogenicus , B. oralis and F. varium with MIC ₅₀ values of 16 μg/mL ^[1] .
Clavulanate potassium (2 μg/mL) raises amoxicillin susceptibility rates for β-lactamase-positive Bacteroides species and fusobacteria from 41.3 to 90.8% and from 64.2 to 88.7%, respectively ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Clavulanate potassium (125 mg; 20 d) protects 75% of mice with experimental pneumonitis compared with no survivors in the control group ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 1 mg/mL (ultrasonic and warming and heat to 80°C)

H ₂ O : < 0.1 mg/mL (insoluble)