Mutabilol
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 332.39 |
| Molecular Formula | C19H24O5 |
| SMILES | O[C@@]12C(C(C(C3=C2C(O)=C(C(C(C)C)=C3)O)=O)=O)C(C)(C)CCC1 |
Summary
Mutabilol (compound 1) is a potent p-glycoprotein (P-gp) regulator. Mutabilol is a nature product could be isolated from Plectranthus mutabilis leaves. Mutabilol increases the P-gp expression in NCI-H460/R cells [1] .
In Vitro
Mutabilol (compound 1; 2, 5, 10, 20, and 50 μM; 72 h) has low toxicity with IC
50
values of >50, >50, and >50 μM for NCI-H460, NCI-H460/R, and MRC-5 cells, respectively
[1]
.
Mutabilol (5 and 10 μM; 72 h) stimulates P-gp activity by a direct interaction and decreases the Rho123 accumulation in NCI-H460/R cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | NCI-H460, NCI-H460/R, and MRC-5 cells |
| Concentration: | 2, 5, 10, 20, and 50 μM |
| Incubation Time: | 72 hours |
| Result: | Showed low toxicity of cancer cell lines (IC 50 >50μM) |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.