[CAS NO. ] 11-Oxomogroside IIa

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PRODUCTS SPECIFICATIONS

Catalog

HY-N7041

Brand

MCE

CAS

-

DESCRIPTION

Overview

MDL	-
Molecular Weight	799.00
Molecular Formula	C42H70O14
SMILES	C[C@H](CC[C@@H](O[C@H]1[C@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](CO)O2)[C@@H](O)[C@H](O)[C@@H](CO)O1)C(C)(O)C)C3CC[C@@]([C@]3(C)C4)(C)C5CC=C6C(C)(C)[C@@H](O)CCC6[C@]5(C)C4=O

For research use only. We do not sell to patients.

Summary

11-Oxomogroside IIa (11-oxomogroside II A1) is a cucurbitane glycoside extracted from the fruits of Siraitia grosVenorii . 11-Oxomogroside IIa has inhibitory effects against the Epstein-Barr virus early antigen ( EBV-EA ) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), shows weak inhibitory effects on activation of (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor ^[1] .

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 62.58 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2516 mL	6.2578 mL	12.5156 mL
5 mM	0.2503 mL	1.2516 mL	2.5031 mL
10 mM	0.1252 mL	0.6258 mL	1.2516 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 1.25 mg/mL (1.56 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1.25 mg/mL (1.56 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1.25 mg/mL (1.56 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Akihisa T, et al. Cucurbitane glycosides from the fruits of Siraitia gros venorii and their inhibitory effects on Epstein-Barr virus activation. J Nat Prod. 2007 May;70(5):783-8. Epub 2007 May 4.