[CAS NO. ] Pepstatin Ammonium

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PRODUCTS SPECIFICATIONS

Catalog

HY-P0018B

Brand

MCE

CAS

-

DESCRIPTION

Overview

MDL	-
Molecular Weight	702.92
Molecular Formula	C34H66N6O9
SMILES	-

For research use only. We do not sell to patients.

17 Publications Citing Use of MCE

Summary

Pepstatin (Pepstatin A) Ammonium is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC ₅₀ s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Ammonium also inhibits HIV protease ^[1] ^[2] .

IC50 & Target

IC50: 4.5 nM (Hemoglobin-pepsin), 6.2 nM (Hemoglobin-proctase), 150 nM (Casein-pepsin), 260 nM (Hemoglobin-acid protease), 290 nM (Casein-proctase), 520 nM (Casein-acid protease) ^[1]

In Vitro

Pepstatin (Pepstatin A) (7 μM; 48 h) affects the intracellular processing of HIV-specific gag protein ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pepstatin (Pepstatin A) has a very low toxicity, with LD ₅₀ s of 1090 mg/kg, 875 mg/kg, 820 mg/kg and 450 mg/kg for mice, rats, rabbits, and dogs by i.p. route, and > 2000 mg/kg for all species by oral route ^[1] .
Pepstatin (0.5-50 mg/kg, p.o.) suppresses stomach ulceration of the pylorus in ligated Shay rats ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Pylorus ligated male Wistar rats ^[1]
Dosage:	0.5, 1, 10 and 50 mg/kg
Administration:	Oral administration, 15 minutes after pyloric ligation
Result:	Effectively prevented stomach ulceration.

Appearance

Solid

Source

Actinomyces

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 41.67 mg/mL ( 59.28 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4226 mL	7.1132 mL	14.2264 mL
5 mM	0.2845 mL	1.4226 mL	2.8453 mL
10 mM	0.1423 mL	0.7113 mL	1.4226 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (2.96 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.08 mg/mL (2.96 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (2.96 mM); Clear solution

* All of the co-solvents are available by MCE.