[CAS NO. ] R18 TFA

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PRODUCTS SPECIFICATIONS

Catalog

HY-P1039A

Brand

MCE

CAS

-

DESCRIPTION

Overview

MDL	-
Molecular Weight	2423.73
Molecular Formula	C103H158F3N27O31S3
SMILES	-

For research use only. We do not sell to patients.

Summary

R18 TFA is a peptide antagonists of 14-3-3 , with a K _D of 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinase Raf-1 , a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1 ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H ₂ O : ≥ 25 mg/mL ( 10.31 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.4126 mL	2.0629 mL	4.1259 mL
5 mM	0.0825 mL	0.4126 mL	0.8252 mL
10 mM	0.0413 mL	0.2063 mL	0.4126 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1] B Wang, et al. Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display. Biochemistry. 1999 Sep 21;38(38):12499-504.