NGR peptide Trifluoroacetate
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 722.72 |
| Molecular Formula | C22H37F3N10O10S2 |
| SMILES | - |
Summary
NGR peptide Trifluoroacetate containing the asparagine-glycine-arginine (NGR) motif is recognized by CD13 / aminopeptidase N ( APN ) receptor isoforms that are selectively overexpressed in tumor neovasculature.
IC50 & Target
CD13/aminopeptidase N (APN) receptor [1]
In Vitro
NGR peptide can selectively bind to APN/CD13 either immune-captured or expressed on the surface of cells, the receptor of the tumor-homing NGR peptide was suspected to be APN/CD13. The NGR peptide is reported to have the greatest tumor selectivity. An anti-cancer drug Doxorubicin (DOX) coupled to an NGR peptide displays enhanced anti-tumor effects with even lower toxicity than the free drug itself [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
NGR peptide imaging in vivo not only provides more insight into NGR’s targeting process, including bio-distribution and pharmacokinetics, but also reveals angiogenic activities related to tumor progression and malignancy [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Sealed storage, away from moisture
| Powder | -80°C | 2 years |
|---|---|---|
| -20°C | 1 year |
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 50 mg/mL ( 69.18 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.3837 mL | 6.9183 mL | 13.8366 mL |
| 5 mM | 0.2767 mL | 1.3837 mL | 2.7673 mL |
| 10 mM | 0.1384 mL | 0.6918 mL | 1.3837 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (138.37 mM); Clear solution; Need ultrasonic
References