Urotensin II (114-124), human TFA
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 1502.59 |
| Molecular Formula | C66H86F3N13O20S2 |
| SMILES | - |
Summary
Urotensin II (114-124), human TFA, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14 .
IC50 & Target
GPR14 [1]
In Vitro
Human Urotensin II (U-II) binds to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization. Human Urotensin II induces concentration-dependent increases in intracellular calcium in a HEK-293 cell line expressing human GPR14 (EC 50 =0:62±0.17 nM, n=6) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Human Urotensin II (U-II) markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Sealed storage, away from moisture
| Powder | -80°C | 2 years |
|---|---|---|
| -20°C | 1 year |
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 100 mg/mL ( 66.55 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.6655 mL | 3.3276 mL | 6.6552 mL |
| 5 mM | 0.1331 mL | 0.6655 mL | 1.3310 mL |
| 10 mM | 0.0666 mL | 0.3328 mL | 0.6655 mL |
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1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (66.55 mM); Clear solution; Need ultrasonic