[CAS NO. ] Kisspeptin-10 (mouse, rat) (TFA)

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PRODUCTS SPECIFICATIONS

Catalog

HY-P1197A

Brand

MCE

CAS

-

DESCRIPTION

Overview

MDL	-
Molecular Weight	1432.46
Molecular Formula	C65H84F3N17O17
SMILES	-

For research use only. We do not sell to patients.

Summary

Kisspeptin-10, rat TFA is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, rat TFA is a ligand for the rodent kisspeptin receptor (KISS1, GPR54). Kisspeptin-10 TFA reduces Methotrexate-induced reproductive toxicity as a potential antioxidant compound ^[1] .

IC50 & Target

GPR54 ^[1]
Angiogenesis ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : ≥ 50 mg/mL ( 34.90 mM )

H ₂ O : 10 mg/mL ( 6.98 mM ; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.6981 mL	3.4905 mL	6.9810 mL
5 mM	0.1396 mL	0.6981 mL	1.3962 mL
10 mM	0.0698 mL	0.3490 mL	0.6981 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (1.75 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (1.75 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (1.75 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Güvenç M, et al. Ameliorating effect of kisspeptin-10 on methotrexate-induced sperm damages and testicular oxidative stress in rats. Andrologia. 2018 Oct;50(8):e13057.