Transdermal Peptide Disulfide TFA
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 1175.17 |
| Molecular Formula | C42H65F3N14O18S2 |
| SMILES | - |
Summary
Transdermal Peptide Disulfide TFA (TD 1 Disulfide(peptide) TFA) is a 11-amino acid peptide, binds to Na + /K + -ATPase beta-subunit (ATP1B1) , and mainly interacts with the C-terminus of ATP1B1 . Transdermal Peptide Disulfide TFA can enhance the transdermal delivery of many macromolecules [1] .
In Vitro
In the presence of Transdermal Peptide Disulfide, because of the specific binding of Transdermal Peptide Disulfide to ATP1B1, cells will upregulate the level of ATP1B1 to maintain function and structure; as a result, the expression of ATP1B1 increases. However, as time goes on, some Transdermal Peptide Disulfide molecules may be transported into cells by endocytosis; consequently, the expression of ATP1B1 then decreases. The interaction between Transdermal Peptide Disulfide and ATP1B1 changes not only the expression of ATP1B1, but also the localization of ATP1B1 and then the structure of the epidermal layer. This interaction can be attenuated by inhibitors or competitors, which would result in the reduced delivery of macromolecular drugs across the skin [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Sealed storage, away from moisture
| Powder | -80°C | 2 years |
|---|---|---|
| -20°C | 1 year |
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 100 mg/mL ( 85.09 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.8509 mL | 4.2547 mL | 8.5094 mL |
| 5 mM | 0.1702 mL | 0.8509 mL | 1.7019 mL |
| 10 mM | 0.0851 mL | 0.4255 mL | 0.8509 mL |
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1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (85.09 mM); Clear solution; Need ultrasonic