Notch 1 TFA
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 1614.81 |
| Molecular Formula | C64H98N15F3O25S3 |
| SMILES | [NH2-CLDQIGEFQCICE-COOH (TFA salt)] |
Summary
Notch 1 TFA (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types [1] .
In Vitro
Notch 1 is shown to promote mouse luminal prostate cell survival and proliferation through the activation of the prosurvival NF-κB pathway
[2]
.
Down-regulation of Notch 1 and Jagged1 in human prostate cancer cell lines decreases in vitro invasion and cell growth
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Sealed storage, away from moisture
| Powder | -80°C | 2 years |
|---|---|---|
| -20°C | 1 year |
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 18.52 mg/mL ( 11.47 mM ; ultrasonic and adjust pH to 9 with NaOH)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.6193 mL | 3.0963 mL | 6.1927 mL |
| 5 mM | 0.1239 mL | 0.6193 mL | 1.2385 mL |
| 10 mM | 0.0619 mL | 0.3096 mL | 0.6193 mL |
References