[CAS NO. ] JTP10-△-R9 TFA

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PRODUCTS SPECIFICATIONS

Catalog

HY-P2247

Brand

MCE

CAS

-

DESCRIPTION

Overview

MDL	-
Molecular Weight	2860.31
Molecular Formula	C119H214F3N53O26
SMILES	-

For research use only. We do not sell to patients.

Summary

JTP10-△-R9 TFA is a selective JNK2 peptide inhibitor, with an IC ₅₀ of 89 nM, exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3 ^[1] .

IC50 & Target

JNK2

89 nM (IC ₅₀ )

JNK1

1.1 μM (IC ₅₀ )

JNK3

1.2 μM (IC ₅₀ )

In Vitro

JTP10-△-R9 TFA inhibits the migration of PyVMTjnk ^2+/+ cells and PyVMTjnk ^2-/- cells expressing GFP-JNK2α ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H ₂ O : 25 mg/mL ( 8.74 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.3496 mL	1.7481 mL	3.4961 mL
5 mM	0.0699 mL	0.3496 mL	0.6992 mL
10 mM	---	---	---

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Tamer S. Kao, et al. Development of JNK2-selective peptide inhibitors that inhibit breast cancer cell migration. ACS Chem Biol. 2011 Jun 17;6(6):658-66.