KRpep-2d TFA
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 2675.03 |
| Molecular Formula | C110H183F3N44O27S2 |
| SMILES | - |
Summary
IC50 & Target
|
K-RAS |
In Vitro
KRpep-2d (TFA) has cyclic structure with importance for K-Ras inhibitory activity. Leu
7
7 , Ile
9
, and Asp
12
are critical amino acid residues for the K-Ras inhibitory activity of KRpep-2d
[1]
.
KRpep-2d (TFA) (10-30 μM) has inhibitory activity of A427 cells with the proliferation rates of 68.3% (10 μM) and 48.3% (10 μM)
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Sealed storage, away from moisture and light, under nitrogen
| Powder | -80°C | 2 years |
|---|---|---|
| -20°C | 1 year |
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Solvent & Solubility
H 2 O : 100 mg/mL ( 37.38 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.3738 mL | 1.8691 mL | 3.7383 mL |
| 5 mM | 0.0748 mL | 0.3738 mL | 0.7477 mL |
| 10 mM | 0.0374 mL | 0.1869 mL | 0.3738 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (18.69 mM); Clear solution; Need ultrasonic