MDP1 acetate
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 2521.05 |
| Molecular Formula | C113H206N34O30 |
| SMILES | - |
Summary
MDP1 acetate, a Melittin-derived peptide, alters the integrity of both Gram-positive and Gram-negative bacterial membranes and kills the bacteria via membrane damages. MDP1 acetate has a high-antibacterial activity against multidrug resistant (MDR) and reference strains of S. aureus , E. coli , and P. aeruginosa [1] .
In Vitro
MDP1 acetate exhibits more potent antibacterial activities against
S. aureus
,
E. coli
and
P. aeruginosa
.
Geometric means of MICs for MDP1 is recorded at 4.06 μg/mL (
S. aureus
), 1.22 μg/mL (
E. coli
) and 3.75 μg/mL (
P. aeruginosa
), respectively
[1]
.
DNA and calcein release and flow cytometry assays indicate a time-dependent antibacterial activity on the examined bacteria affected by MDP1 (10, 5, 2.5, 1.25, 0.625 and 0.312 μg/mL) acetate. Finally, SEM analyses highlights dose- and time-dependent effects of MDP1 acetate on
S. aureus
and
E. coli
bacteria by induction of vesicle or pore formation as well as cell lysis
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Sealed storage, away from moisture and light, under nitrogen
| Powder | -80°C | 2 years |
|---|---|---|
| -20°C | 1 year |
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Solvent & Solubility
H 2 O : 10 mg/mL ( 3.97 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.3967 mL | 1.9833 mL | 3.9666 mL |
| 5 mM | --- | --- | --- |
| 10 mM | --- | --- | --- |
-
1.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (19.83 mM); Clear solution; Need ultrasonic
