[CAS NO. 2561494-77-5] UNC6934
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PRODUCTS SPECIFICATIONS [2561494-77-5]
Catalog
SLK-E1059
Brand
Selleck
CAS
2561494-77-5
DESCRIPTION [2561494-77-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 443.46 |
| Molecular Formula | C24H21N5O4 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2550 mL | 11.2750 mL | 22.5499 mL |
| 5 mM | 0.4510 mL | 2.2550 mL | 4.5100 mL |
| 10 mM | 0.2255 mL | 1.1275 mL | 2.2550 mL |
| 50 mM | - | - | - |
Description
UNC6934 is a a chemical probe targeting the . UNC6934 is a potent antagonist of with a Kd (SPR) of 80 nM and is selective for NSD2-PWWP1 over 14 other PWWP domains including NSD3-PWWP1 UNC6934 disrupts the NSD2-PWWP1 interaction with H3K36me2 nucleosomes in U2OS cells as measured by a NanoBret assay with an IC50 of 1.09 μM.
In vitro
UNC6934-mediated antagonism of PWWP1 leads to accumulation of endogenous NSD2 in the nucleolus.
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