[CAS NO. 1448297-52-6] (S,R,S)-AHPC (MDK7526)
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PRODUCTS SPECIFICATIONS [1448297-52-6]
Store
Catalog
SLK-S0097
Brand
Selleck
CAS
1448297-52-6
DESCRIPTION [1448297-52-6]
Overview
| MDL | MFCD29049827 |
|---|---|
| Molecular Weight | 430.56 |
| Molecular Formula | C22H30N4O3S |
| SMILES | O=C([C@H]1N(C([C@@H](N)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3226 mL | 11.6128 mL | 23.2256 mL |
| 5 mM | 0.4645 mL | 2.3226 mL | 4.6451 mL |
| 10 mM | 0.2323 mL | 1.1613 mL | 2.3226 mL |
| 50 mM | 0.0465 mL | 0.2323 mL | 0.4645 mL |
Description
(S,R,S)-AHPC (MDK7526, VH032-NH2, VHL ligand 1) is the used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC is potential useful for the targeted degradation of the . (S,R,S)-AHPC can be connected to the ligand for protein such as BCR-ABL1 by a linker to form PROTACs such as GMB-475. GMB-475 induces the degradation of BCR-ABL1 with IC50 of 1.11 μM in Ba/F3 cells.
Targets
| Androgen Receptor [1] |
References
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