[CAS NO. 1451255-59-6] KAN0438757

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PRODUCTS SPECIFICATIONS [1451255-59-6]

Catalog

SLK-S0400

Brand

Selleck

CAS

1451255-59-6

DESCRIPTION [1451255-59-6]

Overview

MDL	-
Molecular Weight	447.43
Molecular Formula	C21H18FNO7S
SMILES	-

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

KAN0438757 is a potent and selective inhibitor of the metabolic kinase with IC50 of 0.19 μM and 3.6 μM for PFKFB3 and PFKFB4, respectively.

Targets

PFKFB3 ^[1] (Cell-free assay)	PFKFB4 ^[1] (Cell-free assay)
0.19 μM	3.6 μM

In vitro

A PFKFB3 inhibitor, KAN0438757, which selectively inhibits proliferation of transformed cells while sparing non-transformed cells. Inhibition of PFKFB3 enzymatic activity by KAN0438757 impairs IR-induced recruitment of ribonucleotide reductase (RNR) M2 and deoxynucleotide incorporation upon DNA repair.

References

[1] Nina M S Gustafsson, et al. Nat Commun. 2018 Sep 24;9(1):3872.
[2] De Oliveira T, et al. Cancers (Basel). 2021 Feb 28;13(5):1011.