[CAS NO. 1360705-96-9] ML 210

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PRODUCTS SPECIFICATIONS [1360705-96-9]

Catalog

SLK-S0788

Brand

Selleck

CAS

1360705-96-9

DESCRIPTION [1360705-96-9]

Overview

MDL	MFCD22666407
Molecular Weight	475.32
Molecular Formula	C22H20Cl2N4O4
SMILES	O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)C4=NOC(C)=C4[N+]([O-])=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.1038 mL	10.5192 mL	21.0385 mL
5 mM	0.4208 mL	2.1038 mL	4.2077 mL
10 mM	0.2104 mL	1.0519 mL	2.1038 mL
50 mM	0.0421 mL	0.2104 mL	0.4208 mL

Description

ML-210 (CID 49766530) is a selective covalent inhibitor of cellular with EC50 of 0.04 μM and induces . ML-210 can selectively kill cells induced to express mutant . ML-210 exhibits anti-cancer activity.

Targets

RAS ^[1]	GPX4 ^[2] (Cell-free assay)
	0.04 μM(EC50)

In vitro

ML-210 has ICs of 71 nM, 272 nM and 107nM for BJeLR (HRASV12), BJeH-LT (without HRASV12) and DRD cell lines, respectively[2].

References

[1] Michel Weïwer, et al. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6.
[2] Eaton, J.K., et al. Nat Chem Biol. 2020 Mar 30;16:497–506.
[3] Zhao R, et a. Prostate. 2022 Apr;82(5):617-629.