[CAS NO. 1174046-72-0] BMS-794833

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PRODUCTS SPECIFICATIONS [1174046-72-0]

Catalog

SLK-S2201

Brand

Selleck

CAS

1174046-72-0

DESCRIPTION [1174046-72-0]

Overview

MDL	MFCD18206786
Molecular Weight	468.84
Molecular Formula	C23H15ClF2N4O3
SMILES	-

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.1329 mL	10.6646 mL	21.3292 mL
5 mM	0.4266 mL	2.1329 mL	4.2658 mL
10 mM	0.2133 mL	1.0665 mL	2.1329 mL
50 mM	0.0427 mL	0.2133 mL	0.4266 mL

Description

BMS-794833 is a potent ATP competitive inhibitor of with of 1.7 nM/15 nM, also inhibits Ron, Axl and Flt3 with IC50 of <3 nM; a prodrug of BMS-817378. Phase 1.

Targets

Met ^[1]	VEGFR2 ^[1]
1.7 nM	15 nM

In vitro

BMS794833 also inhibits Met receptor activated gastric carcinoma cell line, GTL-16, with IC50 of 39 nM.

In vivo

In GTL-16 human gastric tumor xenografts model, BMS798433 shows greater than 50% TGI for at least one tumor doubling time with no overt toxicity observed during 14 days. BMS798433 also shows complete tumor stasis at a dose of 25 mg/kg against U87 glioblastoma model.

References

[1] WO2009094417A1