[CAS NO. 31993-01-8] SIB 1757

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PRODUCTS SPECIFICATIONS [31993-01-8]

Catalog

SLK-S2645

Brand

Selleck

CAS

31993-01-8

DESCRIPTION [31993-01-8]

Overview

MDL	-
Molecular Weight	213.24
Molecular Formula	C12H11N3O
SMILES	N(=NC1=CC=CC=C1)C2=C(O)C=CC(C)=N2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	4.6896 mL	23.4478 mL	46.8955 mL
5 mM	0.9379 mL	4.6896 mL	9.3791 mL
10 mM	0.4690 mL	2.3448 mL	4.6896 mL
50 mM	0.0938 mL	0.4690 mL	0.9379 mL

Description

SIB 1757 is a highly selective, noncompetitive antagonist of with IC50 of 0.4 μM at hmGluR5 compared with >30 µM at hmGluR1b, hmGluR2, hmGluR4, hmGluR6, hmGluR7 and hmGluR8.

Targets

mGluR5 ^[1]
(Cell-free assay)

0.4 μM

References

[1] Varney MA, et al. J Pharmacol Exp Ther. 1999 Jul;290(1):170-81.

Synonyms

3-Pyridinol, 6-methyl-2-(2-phenyldiazenyl)-

3-Pyridinol, 6-methyl-2-(phenylazo)-

6-Methyl-2-(2-phenyldiazenyl)-3-pyridinol

3-Hydroxy-6-methyl-2-phenylazopyridine

SIB 1757