[CAS NO. 433967-28-3] VU 0357121
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PRODUCTS SPECIFICATIONS [433967-28-3]
Catalog
SLK-S2795
Brand
Selleck
CAS
433967-28-3
DESCRIPTION [433967-28-3]
Overview
| MDL | MFCD03243692 |
|---|---|
| Molecular Weight | 305.32 |
| Molecular Formula | C17H17F2NO2 |
| SMILES | O=C(NC1=CC=C(F)C=C1F)C2=CC=C(OCCCC)C=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.2753 mL | 16.3763 mL | 32.7525 mL |
| 5 mM | 0.6551 mL | 3.2753 mL | 6.5505 mL |
| 10 mM | 0.3275 mL | 1.6376 mL | 3.2753 mL |
| 50 mM | 0.0655 mL | 0.3275 mL | 0.6551 mL |
Description
VU0357121 is a novel positive allosteric modulator (PAM) of with of 33 nM, is inactive or very weakly antagonizing at other mGlu receptor subtypes.
Targets
| mGluR5 [1] |
| 30 nM(EC50) |
In vitro
VU0357121 do not bind at the MPEP allosteric site of mGlu5, thus do not possess mGlu5 NAM activity. The A809V/rmGlu5 mutation inhibited the ability of VU0357121 to shift the glutamate concentration−response curve, whereas the response to VU0357121 is not altered by the F585I/rmGlu5 mutation. VU0357121 show weaker cooperativity in the Ca mobilization assay in the low-expressing HEK293A-mGlu5 cell line.
References
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