[CAS NO. 162831-31-4] IEM 1754 2HBr

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PRODUCTS SPECIFICATIONS [162831-31-4]

Catalog

SLK-S2860

Brand

Selleck

CAS

162831-31-4

DESCRIPTION [162831-31-4]

Overview

MDL	MFCD03105050
Molecular Weight	412.25
Molecular Formula	C16H30N2.2HBr
SMILES	NCCCCCNCC12CC3CC(C2)CC(C3)C1.[H]Br.[H]Br

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.4257 mL	12.1286 mL	24.2571 mL
5 mM	0.4851 mL	2.4257 mL	4.8514 mL
10 mM	0.2426 mL	1.2129 mL	2.4257 mL
50 mM	0.0485 mL	0.2426 mL	0.4851 mL

Description

IEM 1754 2HBr is a selective AMPA/kainate receptor blockers for and with of 6 μM.

Targets

GluR1 ^[1]	GluR3 ^[1]
6 μM	6 μM

In vitro

IEM 1754 is an adamantane derivative. IEM 1754 causes use- and voltage-dependent block of open channels of recombinant AMPA receptors. This antagonism is dependent on receptor subunit composition, channels gated by recombinant, homomeric GluR1 and GluR3 receptors exhibites a higher sensitivity to block than those gated by receptors containing edited GluR2 subunits. IEM-1754 block of GluR2-containing AMPAR is enhanced by hyperpolarization in agreement with the classical single-exponential model. In contrast, the block of GluR2-lacking AMPAR is reduced by hyperpolarization.

References

[1] Magazanik LG, et al. J Physiol, 1997, 505( Pt 3), 655-663.
[2] Tikhonov DB, et al. Br J Pharmacol, 2000, 129(2), 265-274.