[CAS NO. 183133-96-2] Cabazitaxel (XRP6258)

Name: Cabazitaxel (XRP6258)
Brand: Arctom Scientific
SKU: SLK-S3022

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PRODUCTS SPECIFICATIONS [183133-96-2]

Store

Catalog

SLK-S3022

Brand

Selleck

CAS

183133-96-2

DESCRIPTION [183133-96-2]

Overview

MDL	MFCD18827611
Molecular Weight	835.93
Molecular Formula	C45H57NO14
SMILES	O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](OC)C(=O)[C@]3(C)[C@@H](OC)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(OC(C)(C)C)=O)C6=CC=CC=C6)O)=O)C5)[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.1963 mL	5.9814 mL	11.9627 mL
5 mM	0.2393 mL	1.1963 mL	2.3925 mL
10 mM	0.1196 mL	0.5981 mL	1.1963 mL
50 mM	0.0239 mL	0.1196 mL	0.2393 mL

Description

Cabazitaxel (RPR-116258A, XRP6258, TXD 258, Taxoid XRP6258) is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth. Cabazitaxel exerts its effects by inhibiting growth and assembly, processes that are essential for cells to divide. Cabazitaxel induces via the PI3K/Akt/mTOR pathway.

Features

A semi-synthetic derivative of a natural taxoid.

Targets

Microtubule ^[1]
(Cell-free assay)

In vitro

Cabazitaxel increases CYP3A enzyme activities in rat hepatocytes. The mean ex-vivo human plasma protein binding of Cabazitaxel is 91.6%. Cabazitaxel is rapidly and extensively metabolised in numerous metabolites. Cabazitaxel demonstrates activity in several murine and human resistant cell lines. With a 4-day exposure to cabazitaxel, cytotoxicity is noted with relatively low cabazitaxel concentrations. Cabazitaxel shows high antitumor activity in 3 human colorectal cell lines (HCT-116, HCT-8, and HT-29).

References

[1] EMEA/H/C/002018, 2011.
[2] Pal SK, et al. Clin Interv Aging, 2010, 5, 395-402.
[3] Shi Y, et al. Cell Death Dis. 2022 Sep 19;13(9):799.
[4] Tai X, et al. J Drug Target. 2017 Feb;25(2):179-187.

Synonyms

Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-

TXD 258

Cabazitaxel

XRP 6258

Jevtana

DEP cabazitaxel