[CAS NO. 306-07-0] Pargyline hydrochloride

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PRODUCTS SPECIFICATIONS [306-07-0]

Catalog

SLK-S3690

Brand

Selleck

CAS

306-07-0

DESCRIPTION [306-07-0]

Overview

MDL	MFCD00012492
Molecular Weight	195.69
Molecular Formula	C11H13N.HCl
SMILES	C(N(CC#C)C)C1=CC=CC=C1.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	5.1101 mL	25.5506 mL	51.1012 mL
5 mM	1.0220 mL	5.1101 mL	10.2202 mL
10 mM	0.5110 mL	2.5551 mL	5.1101 mL
50 mM	0.1022 mL	0.5110 mL	1.0220 mL

Description

Pargyline is an irreversible inhibitor of with Ki values of 13 and 0.5 μM for time-dependent inhibition of the activity of MAO-A and -B, respectivey.

Targets

MAO-B ^[1] (Cell-free assay)	MAO-A ^[1] (Cell-free assay)
0.5 μM(Ki)	13 μM(Ki)

In vitro

Pargyline, an MAO inhibitor, prevents the activity of lysine-specific demethylase 1 (LSD1) and is excessively expressed in breast cancer. The proliferation of cells exposed to pargyline decreases in a dose- and time-dependent manner. The treatment of 2 mM pargyline exhibits an increase of the cell proportion at the G1 phase, while the major decrease of the cell proportion is at the S phase. pargyline induces an increase in the cleaved PARP expression.

In vivo

Chronic treatment (14 days) with pargyline (10 mg/kg) markedly down-regulate the density of NAIBS (non-adrenoceptor idazoxan binding sites) in the rat brain.

References

[1] Fowler CJ, et al. Biochem Pharmacol. 1982, 31(22):3555-61.
[2] Hyung Tae Lee, et al. Molecular & Cellular Toxicology. 2012, 8(4):393-399.
[3] G. Olmos, et al. Br J Pharmacol. 1993, 108(3): 597-603.

Synonyms

Benzenemethanamine, N-methyl-N-2-propyn-1-yl-, hydrochloride (1:1)

Benzylamine, N-methyl-N-2-propynyl-, hydrochloride

Benzenemethanamine, N-methyl-N-2-propynyl-, hydrochloride

N-Benzyl-N-methyl-2-propynylamine hydrochloride

Eutonyl

N-Methyl-N-(2-propynyl)benzylamine hydrochloride

Pargyline hydrochloride

Methylbenzylpropynylamine hydrochloride

Eutonyl-ten

NSC 43798

MO 911

A 19120