[CAS NO. 57-71-6] 2,3-Butanedione-2-monoxime

Name: 2,3-Butanedione-2-monoxime
Brand: Arctom Scientific
SKU: SLK-S3699

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PRODUCTS SPECIFICATIONS [57-71-6]

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Catalog

SLK-S3699

Brand

Selleck

CAS

57-71-6

DESCRIPTION [57-71-6]

Overview

MDL	MFCD00002116
Molecular Weight	101.10
Molecular Formula	C4H7NO2
SMILES	C(C(C)=O)(=NO)C

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	9.8912 mL	49.4560 mL	98.9120 mL
5 mM	1.9782 mL	9.8912 mL	19.7824 mL
10 mM	0.9891 mL	4.9456 mL	9.8912 mL
50 mM	0.1978 mL	0.9891 mL	1.9782 mL

Description

2,3-Butanedione monoxime (BDM, Diacetyl monoxime, Diacetylmonoxime) is the well-characterized, low-affinity, non-competitive inhibitor of and inhibits skeletal and cardiac muscle contraction.

Targets

skeletal muscle myosin-II ^[1]

In vitro

BDM inhibits skeletal muscle myosin-II, but it does not inhibit the ATPase activity of the other myosins. BDM has a broad effect on many non-myosin proteins (many uncharacterized), and thus should not be used in whole-cell experiments as a myosin inhibitor. BDM inhibits the L-type Ca2+-channel and reduces the opening probability, thereby increasing the closed time of this particular channel. BDM drives nonspecific protein dephosphorylation of many cellular proteins, including ion channels.

In vivo

BDM significant lowers the blood pressure in normo- and hypertensive rats. BDM has been shown to improve right atrial function in a porcine model of allogenic heart transplantation.

References

[1] Ostap EM, et al. J Muscle Res Cell Motil. 2002, 23(4):305-8.
[2] Borlak J, et al. Mol Pharmacol. 2004, 66(3):708-17.

Synonyms

2,3-Butanedione, 2-oxime

2,3-Butanedione, monooxime

2,3-Butanedione oxime

Diacetyl monoxime

2-Oximino-3-butanone

DAM (oxime)

Biacetyl monoxime

3-Oximino-2-butanone

Diacetyl monooxime

2,3-Butanedione monoxime

Biacetyl monooxime

2,3-Butanedione-2-monoxime

2,3-Butanedione 3-monoxime

RA 53

DAM

2-Hydroxyimino-3-butanone

Isonitrosoethyl methyl ketone

3-Oxo-2-butanone oxime

2,3-Butadione monooxime

NSC 116103

NSC 660

3-(Hydroxyimino)-2-butanone