[CAS NO. 19130-96-2] 1-Deoxynojirimycin

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PRODUCTS SPECIFICATIONS [19130-96-2]

Catalog

SLK-S3839

Brand

Selleck

CAS

19130-96-2

DESCRIPTION [19130-96-2]

Overview

MDL	MFCD00063474
Molecular Weight	163.17
Molecular Formula	C6H13NO4
SMILES	C(O)[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	6.1286 mL	30.6429 mL	61.2858 mL
5 mM	1.2257 mL	6.1286 mL	12.2572 mL
10 mM	0.6129 mL	3.0643 mL	6.1286 mL
50 mM	0.1226 mL	0.6129 mL	1.2257 mL

Description

1-Deoxynojirimycin (duvoglustat, moranolin) is a potent inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus.

Targets

α-glucosidase ^[3]
(Cell-free assay)

In vitro

1-Deoxynojirimycin (DNJ) up to 200 μmol/L does not influence survival of HUVECs. DNJ behaves as an antioxidant, decreases ROS production, and delays cellular senescence.

In vivo

1-Deoxynojirimycin (DNJ) inhibits intestinal glucose absorption in intestine. 1-Deoxynojirimycin down-regulates intestinal SGLT1, Na+/K+-ATP and GLUT2 mRNA and protein expression. Pretreatment with DNJ (50 mg/kg) increases the activity, mRNA and protein levels of hepatic glycolysis enzymes (GK, PFK, PK, PDE1) and decreases the expression of gluconeogenesis enzymes (PEPCK, G-6-Pase), improves glucose tolerance in both normal and diabetic mice. DNJ inhibits intestinal glucose absorption and accelerates hepatic glucose metabolism by directly regulating the expression of proteins involved in glucose transport systems, glycolysis and gluconeogenesis enzymes. DNJ reduces oxidative stress in the liver and plasma in rodents.

References

[1] Li YG, et al. Sci Rep. 2013, 3:1377.
[2] E S, et al. Exp Gerontol. 2014, 55:63-9.
[3] Papandréou MJ, et al. Mol Pharmacol. 2002, 61(1):186-93.

Synonyms

3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R,3R,4R,5S)-

Glucopyranose, 5-amino-1,5-dideoxy-, D-

3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, [2R-(2α,3β,4α,5β)]-

(2R,3R,4R,5S)-2-(Hydroxymethyl)-3,4,5-piperidinetriol

Nojirimycin, 1-deoxy-

1-Deoxynojirimycin

D-Glucitol, 1,5-dideoxy-1,5-imino-

Moranoline

5-Amino-1,5-dideoxy-D-glucopyranose

Moranolin

Deoxynojirimycin

BAY-h 5595

1,5-Dideoxy-1,5-imino-D-glucitol

D-1-Deoxynojirimycin

Duvoglustat