[CAS NO. 55203-24-2] Dexamethasone Sodium Phosphate
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PRODUCTS SPECIFICATIONS [55203-24-2]
Store
Catalog
SLK-S4028
Brand
Selleck
CAS
55203-24-2
DESCRIPTION [55203-24-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 516.4 |
| Molecular Formula | C22H30FO8P.2Na |
| SMILES | CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+] |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9365 mL | 9.6824 mL | 19.3648 mL |
| 5 mM | 0.3873 mL | 1.9365 mL | 3.8730 mL |
| 10 mM | 0.1936 mL | 0.9682 mL | 1.9365 mL |
| 50 mM | 0.0387 mL | 0.1936 mL | 0.3873 mL |
Description
Dexamethasone (Dexamethasone 21-phosphate disodium salt) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an modulator that has anti-inflammatory and immunosuppressant effects.
Features
Great selectivity for COX-2.
In vitro
Dexamethasone inhibits COX-2 mRNA expression induced by IL-1 in human articular chondrocytes. Dexamethasone suppresses the cyclooxygenase-2 induction by tumor necrosis factor α (TNFα) with an IC50 of 1 nM in MC3T3-E1 cells. Dexamethasone binds to the glucocorticoid receptor and then to the glucocorticoid response element. Dexamethasone (10 μM) induces osteoblastic differentiation of rat bone marrow stromal cell cultures with elevated mRNA expression of alkaline phosphatase osteopontin, bone sialoprotein, and osteocalcin. Dexamethasone (5 μM) treatment decreases proliferation of adult hippocampal neural progenitor cells and SRE-driven gene expression.
In vivo
Dexamethasone (2 mg/kg) reduces the number of the BrdU-labeled hepatocytes by 80% in male Fischer F344 rats. Dexamethasone (2 mg/kg) pretreatment suppresses the expression of both TNF and IL-6 after partial hepatectomy and significantly reduces the proliferative response of the hepatocytes in male Fischer F344 rats. Dexamethasone also severely diminishes the induction and expansion of oval cells induced by the 2-acetylaminofluorene/partial hepatectomy (AAF/PH) protocol but does not have any effect on the proliferation of the bile duct cells stimulated by bile duct ligation. Dexamethasone (100 μg/kg) produces a significant decrease 59.2% of BrdU(+) hippocampal progenitor cells in Sprague–Dawley rats. Dexamethasone (100 μg/kg) decreases ERK activation in granule cell layer in Sprague–Dawley rats.
References
[1] Blanco FJ, et al. J Rheumatol, 1999, 26(6), 1366-1373.
[2] Yamamoto K, et al. FEBS Lett, 2000, 465(2-3), 103-106.
[3] Rickard DJ, et al. Dev Biol, 1994, 161(1), 218-228.
[4] Nagy P, et al. Hepatology, 1998, 28(2), 423-429.
[5] Kim JB, et al. Brain Res, 2004, 1027(1-2), 1-10.
[6] Wu CY, et al. J Immunol. 1998, 161(6), 2723-2730.
[2] Yamamoto K, et al. FEBS Lett, 2000, 465(2-3), 103-106.
[3] Rickard DJ, et al. Dev Biol, 1994, 161(1), 218-228.
[4] Nagy P, et al. Hepatology, 1998, 28(2), 423-429.
[5] Kim JB, et al. Brain Res, 2004, 1027(1-2), 1-10.
[6] Wu CY, et al. J Immunol. 1998, 161(6), 2723-2730.
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