[CAS NO. 151767-02-1] Montelukast Sodium

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PRODUCTS SPECIFICATIONS [151767-02-1]

Catalog

SLK-S4211

Brand

Selleck

CAS

151767-02-1

DESCRIPTION [151767-02-1]

Overview

MDL	MFCD00931431
Molecular Weight	608.17
Molecular Formula	C35H36ClNO3S.Na
SMILES	C(S[C@H](CCC1=C(C(C)(C)O)C=CC=C1)C2=CC(/C=C/C3=NC4=C(C=C3)C=CC(Cl)=C4)=CC=C2)C5(CC(O)=O)CC5.[Na]

For research use only.

Storage

3 years -20°C powder
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.6443 mL	8.2214 mL	16.4428 mL
5 mM	0.3289 mL	1.6443 mL	3.2886 mL
10 mM	0.1644 mL	0.8221 mL	1.6443 mL
50 mM	0.0329 mL	0.1644 mL	0.3289 mL

Description

Montelukast (MK-0476,Singulair) selectively antagonizes by binding to it so that block the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1. Montelukast improves but not the chaperone-mediated autophagy pathway. .

Targets

CysLT1 ^[1]

In vitro

Montelukast is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Montelukast blocks the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus. This reduces the bronchoconstriction otherwise caused by the leukotriene, and results in less inflammation.

References

[1] Montelukast
[2] Zhang YJ, et al. Acta Pharmacol Sin, 2004, 25(10), 1341-1346

Synonyms

Cyclopropaneacetic acid, 1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-, sodium salt (1:1)

Cyclopropaneacetic acid, 1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-, monosodium salt, [R-(E)]-

Cyclopropaneacetic acid, 1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-, monosodium salt

MK 476

Montelukast sodium

Sodium montelukast

Singulair

Montelukast monosodium salt

2-[1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropyl]acetic acid sodium salt

1-[[[(R)-1-[3-[(E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt

Shantroz

Momazol

Sodium 2-[1-[[[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropyl]acetate

Montair

Montikast

Kokast