[CAS NO. 61-73-4] Methylene Blue

Name: Methylene Blue
Brand: Arctom Scientific
SKU: SLK-S4535

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PRODUCTS SPECIFICATIONS [61-73-4]

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Catalog

SLK-S4535

Brand

Selleck

CAS

61-73-4

DESCRIPTION [61-73-4]

Overview

MDL	MFCD00012111
Molecular Weight	319.85
Molecular Formula	C16H18ClN3S
SMILES	N(C)(C)C1=CC2=C(N=C3C(=[S+]2)C=C(N(C)C)C=C3)C=C1.[Cl-]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.1265 mL	15.6323 mL	31.2647 mL
5 mM	0.6253 mL	3.1265 mL	6.2529 mL
10 mM	0.3126 mL	1.5632 mL	3.1265 mL
50 mM	0.0625 mL	0.3126 mL	0.6253 mL

Description

Methylene Blue (Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015) is used as a dye in chromoendoscopy. It Inhibits with of 1.9μM. Also it inhibits .

Targets

guanylate cyclase ^[3]	Tau aggregation ^[2]
	1.9 μM

In vitro

MB may inhibit the action of nitric oxide synthase itself and could also inactivate nitric oxide directly, possibly through the generation of superoxide anions. In addition to interfering with the nitric oxide–cyclic guanosine monophosphate pathway, MB has also been shown to directly activate calcium-dependent potassium channels and to enhance release of noradrenaline from intracellular stores.

In vivo

Methylene Blue acts by inhibiting guanylate cyclase, thus decreasing C-GMP and vascular smooth muscle relaxation. When injected intravenously, MB selectively accumulates in parathyroid glands, thereby facilitating the identification of these structures during surgery. Pharmacokinetic studies in rodents revealed that intravascular administration of MB leads to a rapid and extensive accumulation of this drug in the central nervous system (CNS).

References

[1] Vutskits L, et al. Anesthesiology. 108(4):684-692.
[2] Hochgr鋐e K, et al. Acta Neuropathol Commun. 2015, 3:25.
[3] Masaki E, et al. Anesth Analg. 1999, 89(2):484-489.
[4] Ginimuge PR, et al. J Anaesthesiol Clin Pharmacol. 2010, 26(4):517-520.

Synonyms

Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride (1:1)

C.I. Basic Blue 9

Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride

C.I. 52015

Aizen Methylene Blue FZ

Aizen Methylene Blue BH

Calcozine Blue ZF

Chromosmon

Hidaco Methylene Blue Salt Free

Leather Pure Blue HB

Methylene Blue D

Methylene Blue 2BP

Methylene Blue BBA

Methylene Blue A

Methylene Blue G

Methylene Blue 2BF

Methylene Blue 2B

Methylene Blue 2BN

Methylene Blue BD

Methylene Blue N

Methylene Blue BP

Methylene Blue BPC

Methylene Blue BX

Methylene Blue BZ

Methylene Blue chloride

Methylene Blue FZ

Methylene Blue GZ

Methylene Blue JFA

Methylene Blue NF

Methylene Blue NZ

Methylene Blue SG

Methylene Blue SP

Methylene Blue ZF

Methylene Blue Zinc Free

Methylene Blue ZX

Methylenium ceruleum

Methylthionine chloride

Methylthioninium chloride

Mitsui Methylene Blue

Schultz 1038

Swiss blue

Tetramethylthionine chloride

Yamamoto Methylene Blue B

Yamamoto Methylene Blue ZF

Ext D and C Blue No. 1

Methylene Blue B

Methylene blue

Basic Blue 9

Methylene Blue BB

Methylene Blue Iad

Methylene Blue HGG

Methylene blue polychrome

Sandocryl Blue BRL

External Blue 1

Tetramethylthionine

Duasyn Basic Blue IAD

Methylene Blue MB

Basic Lake Blue

Urolene Blue

Solvent Blue 8

C.I. Solvent Blue 8

Izit Crystal Dye

NSC 617593

Maxilon Blue SG

BIVN 401

Virostat

Suvus

Proveblue

Basic Blue 2B

TRx 0237

Methylene Blue solution alkaline according to Loeffler

Loffler's alkaline Methylene Blue

3,7-Bis(dimethylamino)-5λ4-phenothiazin-5-ylium chloride

Methylthioninium chloride Proveblue

Sigma A 4043