[CAS NO. 6398-98-7] Amodiaquine dihydrochloride dihydrate

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PRODUCTS SPECIFICATIONS [6398-98-7]

Catalog

SLK-S4589

Brand

Selleck

CAS

6398-98-7

DESCRIPTION [6398-98-7]

Overview

MDL	MFCD09260307
Molecular Weight	464.81
Molecular Formula	C20H22ClN3O.2HCl.2H2O
SMILES	N(C=1C2=C(C=C(Cl)C=C2)N=CC1)C3=CC(CN(CC)CC)=C(O)C=C3.Cl.O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.1514 mL	10.7571 mL	21.5142 mL
5 mM	0.4303 mL	2.1514 mL	4.3028 mL
10 mM	0.2151 mL	1.0757 mL	2.1514 mL
50 mM	0.0430 mL	0.2151 mL	0.4303 mL

Description

Amodiaquine is a potent, non-competitive inhibitor of with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent.

Targets

histamine N-methyl transferase ^[2]
(Cell-free assay)

18.6 nM(Ki)

In vivo

In vivo administration of a small dose amodiaquine dramatically enhanced the effect of histamine on the gastric secretion in dogs. Amodiaquine prevents severe hepatic injury and high lethality in P. acnes-primed and LPS-induced hepatitis mice. Its treatment enhances the elevation of histamine in the liver of P. acnes-primed and LPS-induced hepatitis mice without accompanying tele-methyl histamine elevation.

References

[1] Yokoyama A, et al. Eur J Pharmacol. 2007, 558(1-3):179-84.
[2] Horton JR, et al. J Mol Biol. 2005, 353(2):334-344.
[3] Barth H, et al. Br J Pharmacol. 1975, 55(3):321-327.

Synonyms

Phenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-, hydrochloride, hydrate (1:2:2)

o-Cresol, 4-[(7-chloro-4-quinolyl)amino]-α-(diethylamino)-, dihydrochloride, dihydrate

Phenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-, dihydrochloride, dihydrate

Amodiaquin dihydrochloride dihydrate

Amodiaquine dihydrochloride dihydrate