[CAS NO. 182004-65-5] KB-R7943 mesylate

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PRODUCTS SPECIFICATIONS [182004-65-5]

Catalog

SLK-S4643

Brand

Selleck

CAS

182004-65-5

DESCRIPTION [182004-65-5]

Overview

MDL	MFCD00952138
Molecular Weight	427.5
Molecular Formula	C17H21N3O6S2
SMILES	S(C)(=O)(=O)O.C(OC1=CC=C(CCSC(=N)N)C=C1)C2=CC=C(N(=O)=O)C=C2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.3392 mL	11.6959 mL	23.3918 mL
5 mM	0.4678 mL	2.3392 mL	4.6784 mL
10 mM	0.2339 mL	1.1696 mL	2.3392 mL
50 mM	0.0468 mL	0.2339 mL	0.4678 mL

Description

KB-R7943 mesylate is a widely used inhibitor of the reverse with IC50 of 5.7 μM. KB-R7943 mesylate promotes prostate cancer cell death by activating the pathway and blocking .

Targets

NCX(rev) ^[1]
(Cell-free assay)

5.7 μM

In vitro

KB-R7943 inhibits the reverse NCX more potently than its forward mode, thus occludes NCX-mediated Ca2+ extrusion and elevates intracellular Ca level of melanoma.

References

[1] Tatiana Brustovetsky, et al. Br J Pharmacol. 2011 Jan;162(1):255-70.
[2] Zhou Long, et al. Oncotarget. 2016 Jul 5;7(27):42059-42070.
[3] Liu Z, et al. Int J Mol Sci. 2022 Jan 14;23(2):901.

Synonyms

Carbamimidothioic acid, 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester, methanesulfonate (1:1)

Carbamimidothioic acid, 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester, monomethanesulfonate

2-[4-[(4-Nitrophenyl)methoxy]phenyl]ethyl carbamimidothioate methanesulfonate (1:1)

KB-R 7943