[CAS NO. 145821-59-6] Tiagabine hydrochloride

Name: Tiagabine hydrochloride
Brand: Arctom Scientific
SKU: SLK-S4661

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PRODUCTS SPECIFICATIONS [145821-59-6]

Distributor

Catalog

SLK-S4661

Brand

Selleck

CAS

145821-59-6

DESCRIPTION [145821-59-6]

Overview

MDL	MFCD07369025
Molecular Weight	412.01
Molecular Formula	C20H25NO2S2.HCl
SMILES	C(=CCCN1C[C@H](C(O)=O)CCC1)(C2=C(C)C=CS2)C3=C(C)C=CS3.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.4271 mL	12.1356 mL	24.2713 mL
5 mM	0.4854 mL	2.4271 mL	4.8543 mL
10 mM	0.2427 mL	1.2136 mL	2.4271 mL
50 mM	0.0485 mL	0.2427 mL	0.4854 mL

Description

Tiagabine Hydrochloride (Gabitril, NO050328, NO328, TGB) is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective inhibitor.

Targets

GABA uptake ^[1]

In vitro

Tiagabine is a potent inhibitor of GABA uptake into neurons and glial cells. It is involved in modulating GABA levels, especially in areas such as the hippocampus and thalamus. Tiagabine not only affected the decay kinetics of the IPSCs, it also reduced the frequency of occurrence of both spontaneous and miniature IPSCs.

In vivo

Tiagabine offers a significant neuroprotection in global ischemia in gerbils when given 30 min before ischemia but not when given 3 h after ischemia.

References

[1] Hu RQ, et al. Brain Res. 1997, 753(2):260-8.
[2] Angehagen M, et al. Neurochem Res. 2003, 28(2):333-40.
[3] Iqbal S, et al. Brain Res. 2002, 946(2):162-70.
[4] Chen L, et al. Exp Brain Res. 2003, 152(2):263-9.

Synonyms

3-Piperidinecarboxylic acid, 1-[4,4-bis(3-methyl-2-thienyl)-3-buten-1-yl]-, hydrochloride (1:1), (3R)-

3-Piperidinecarboxylic acid, 1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-, hydrochloride, (R)-

3-Piperidinecarboxylic acid, 1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-, hydrochloride, (3R)-

Tiagabine hydrochloride

Abbott 70569.1

Abbott 70569 hydrochloride

ABT 569

NO 05-0328

NNC 05-0328

Tiabex

Gabitril

(3R)-1-[4,4-Bis(3-methylthien-2-yl)-3-butenyl]piperidine-3-carboxylic acid hydrochloride

(3R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-en-1-yl]piperidine-3-carboxylic acid hydrochloride