[CAS NO. 201677-61-4] Sivelestat sodium tetrahydrate

Name: Sivelestat sodium tetrahydrate
Brand: Arctom Scientific
SKU: SLK-S4666

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PRODUCTS SPECIFICATIONS [201677-61-4]

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Catalog

SLK-S4666

Brand

Selleck

CAS

201677-61-4

DESCRIPTION [201677-61-4]

Overview

MDL	MFCD01937969
Molecular Weight	528.51
Molecular Formula	C20H21N2O7S.4H2O.Na
SMILES	C(NCC(O)=O)(=O)C1=C(NS(=O)(=O)C2=CC=C(OC(C(C)(C)C)=O)C=C2)C=CC=C1.[Na].O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.8921 mL	9.4606 mL	18.9211 mL
5 mM	0.3784 mL	1.8921 mL	3.7842 mL
10 mM	0.1892 mL	0.9461 mL	1.8921 mL
50 mM	0.0378 mL	0.1892 mL	0.3784 mL

Description

Sivelestat sodium tetrahydrate (ONO5046-Na, EI546, LY544349) is a competitive inhibitor of , also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse.

Targets

neutrophil elastase ^[1]

In vitro

Sivelestat suppresses both adhesion and transmigration of neutrophils to the endothelium.

In vivo

Intraoperative administration of sivelestat effectively reduced neutrophil induction and activation in the lung and improved oxygenation after cardiopulmonary bypass in a piglet model.By inhibiting neutrophil elastase, sivelestat has a direct action to the accumulated and activated leucocytes, offering efficient protection against the production of oxygen radicals and cytokines.

References

[1] Ando M, et al. Interact Cardiovasc Thorac Surg. 2016, 7(5):785-8.
[2] Sakai S, et al. Dig Dis Sci. 2014, 59(4):787-94.
[3] Tsounapi P, et al. BJU Int. 2011, 107(2):329-36.

Synonyms

Propanoic acid, 2,2-dimethyl-, 4-[[[2-[[(carboxymethyl)amino]carbonyl]phenyl]amino]sulfonyl]phenyl ester, sodium salt, hydrate (1:1:4)

Glycine, N-[2-[[[4-(2,2-dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-, monosodium salt, tetrahydrate

LY 544349 sodium tetrahydrate

Sivelestat sodium tetrahydrate

Elaspol 100

Elaspol