[CAS NO. 20362-31-6] Arctiin

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PRODUCTS SPECIFICATIONS [20362-31-6]

Catalog

SLK-S4738

Brand

Selleck

CAS

20362-31-6

DESCRIPTION [20362-31-6]

Overview

MDL	MFCD00870630
Molecular Weight	534.55
Molecular Formula	C27H34O11
SMILES	C([C@@H]1[C@@H](CC2=CC(OC)=C(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C=C2)C(=O)OC1)C4=CC(OC)=C(OC)C=C4

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.8707 mL	9.3537 mL	18.7073 mL
5 mM	0.3741 mL	1.8707 mL	3.7415 mL
10 mM	0.1871 mL	0.9354 mL	1.8707 mL
50 mM	0.0374 mL	0.1871 mL	0.3741 mL

Description

Arctiin (Arctigenin-4-Glucoside, NSC 315527) acts on an agonists of the with anti-cancer effects.

Targets

adiponectin receptor 1 ^[3]

In vitro

Arctiin induces growth inhibition and dephosphorylates the tumor-suppressor retinoblastoma protein in human immortalized keratinocyte HaCaT cells. The growth inhibition caused by arctiin is associated with the downregulation of cyclin D1 protein expression. The arctiin-induced suppression of cyclin D1 protein expression occurs in various types of human tumor cells, including osteosarcoma, lung, colorectal, cervical and breast cancer, melanoma, transformed renal cells and prostate cancer.

In vivo

Arctiin has anti-cancer properties in animal models. arctiin has a remarkable anti-tumor-promoting effect as seen in a two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[α]anthracene(DMBA) as an initiator and 12-Otetradecanoyl phorbol-13-acetate (TPA) as a promoter by topical and oral administration. It also has a protective effect on 2-amino-1-methyl-6- phenylimidazo[4,5-β]pyridine (PhIP)-induced carcinogenesis particularly in the mammary gland during the promotion period. Arctiin is orally effective against either IFV-inoculated normal or 5-fluorouracil (5-FU)-treated mice.

References

[1] Matsuzaki Y, et al. Oncol Rep. 2008, 19(3):721-7.
[2] Hayashi K, et al. Biol Pharm Bull. 2010, 33(7):1199-205.
[3] Sun Y, et al. PLoS One. 2013, 8(5):e63354.

Synonyms

2(3H)-Furanone, 4-[(3,4-dimethoxyphenyl)methyl]-3-[[4-(β-D-glucopyranosyloxy)-3-methoxyphenyl]methyl]dihydro-, (3R,4R)-

Arctiin

2(3H)-Furanone, 4-[(3,4-dimethoxyphenyl)methyl]-3-[[4-(β-D-glucopyranosyloxy)-3-methoxyphenyl]methyl]dihydro-, (3R-trans)-

(3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]-3-[[4-(β-D-glucopyranosyloxy)-3-methoxyphenyl]methyl]dihydro-2(3H)-furanone

Arctigenin-4-glucoside

NSC 315527

Arctii

Arctin