[CAS NO. 78-70-6] Linalool

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PRODUCTS SPECIFICATIONS [78-70-6]

Catalog

SLK-S4957

Brand

Selleck

CAS

78-70-6

DESCRIPTION [78-70-6]

Overview

MDL	MFCD00008906
Molecular Weight	154.25
Molecular Formula	C10H18O
SMILES	C(CCC=C(C)C)(C=C)(C)O

For research use only.

Storage

2 years -80 in solvent
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Linalool (Phantol), a monoterpene compound commonly found as major component of essential oils of several aromatic species, is a competitive antagonist of .

Targets

NMDAR ^[2]

In vitro

Linalool exhibits a good cytotoxic effect on U937 and HeLa cells, with the IC50 value of 2.59 and 11.02 μM, respectively. Linalool inhibits the growth of various human cancer cells by causing apoptotic cell death. It can induce the cell cycle of U937 cells to arrest at the G0/G1 phase, while HeLa cells arrest at the G2/M phase, and its function facilitates the expression of p53, p21, p27, p16, and p18 (CDKIs) and the non-expression of CDK activity. Linalool non-selectively suppresses the voltage-gated currents in newt sensory neurons and rat cerebellar Purkinje cells.

In vivo

Linalool (i.p. 10-200mg/kg; p.o., 5-100mg/kg) shows significant antinociceptive activity against glutamate induced pain in mice, possible due mechanisms operated by ionotropic glutamate receptors, namely AMPA, NMDA and kainate but not via metabotropic receptors. Linalool (50-150mg/kg, s.c.) shows antinociceptive activity in formalin and hot-plate tests. This effect is mediated by NMDA, opioid dopamine D2, muscarinic M2 receptors and KATP channels. Linalool (50 and 100mg/kg doses) impairs long-term memory acquisition, but not short-term memory acquisition, in the object recognition task in rats.

References

[1] Hosseinzadeh H, et al. Phytother Res. 2012, 26(9):1399-404.
[2] Coelho VR, et al. Phytomedicine. 2011, 18(10):896-901.
[3] Mei-Yin Chang, et al. Int J Mol Sci. 2015, 16(12): 28169-28179.
[4] Narusuye K, et al. J Neural Transm (Vienna). 2005, 112(2):193-203.

Synonyms

1,6-Octadien-3-ol, 3,7-dimethyl-

3,7-Dimethyl-1,6-octadien-3-ol

2,6-Dimethyl-2,7-octadien-6-ol

Linalol

Linalool

Linalyl alcohol

β-Linalool

3,7-Dimethyl-1,6-octadiene-3-ol

Linanool

dl-Linalool

(±)-Linalool

NSC 3789

L 260-2

2-Methyl-1-prenyl-3-buten-2-ol

3,7-Dimethyl-3-hydroxy-1,6-octadiene

3,7-Dimethyl-3-ol-1,6-octadiene

Phantol