[CAS NO. 1783-96-6] D-Aspartic acid

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PRODUCTS SPECIFICATIONS [1783-96-6]

Catalog

SLK-S5129

Brand

Selleck

CAS

1783-96-6

DESCRIPTION [1783-96-6]

Overview

MDL	MFCD00063081
Molecular Weight	133.10
Molecular Formula	C4H7NO4
SMILES	[C@@H](CC(O)=O)(C(O)=O)N

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	7.5131 mL	37.5657 mL	75.1315 mL
5 mM	1.5026 mL	7.5131 mL	15.0263 mL
10 mM	0.7513 mL	3.7566 mL	7.5131 mL
50 mM	-	-	-

Description

D-Aspartic acid (D-Asp, Aminosuccinic acid, asparagic acid, asparaginic acid) is an endogenous amino acid occurring in several tissues and cells of both invertebrates and vertebrates. It can regulate testosterone synthesis and may act on a stimulatory receptor ().

In vitro

D-aspartate (D-Asp) is an endogenous amino acid present in vertebrate tissues, with particularly high levels in the testis. In vitro studies have demonstrated that D-Asp up-regulates testosterone production in Leydig cells by enhancing expression of the steroidogenic acute regulatory protein. Besides testosterone release, D-Asp induced E2 synthesis through aromatase activation.

In vivo

In vivo studies indicate that D-Asp indirectly stimulates spermatogenesis through the hypothalamic-pituitary-gonadal axis. The oral and/or intraperitoneal D-Asp administration to adult rats induced an increase of serum progesterone and LH as well as an increase of testis/serum testosterone levels, whereas 17β-estradiol (E2) levels did no change. D-aspartic acid has significant analgesic activity.

References

[1] Santillo A, et al. J Cell Physiol. 2016, 231(2):490-5.
[2] Onat F, et al. Pharmacol Biochem Behav. 1995, 51(4):715-9.

Synonyms

D-Aspartic acid

Aspartic acid, D-

(-)-Aspartic acid

D-(-)-Aspartic acid

(R)-Aspartic acid

NSC 97922

(2R)-2-Aminobutanedioic acid

(R)-2-Aminosuccinic acid