[CAS NO. 388082-78-8] Lapatinib ditosylate monohydrate

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PRODUCTS SPECIFICATIONS [388082-78-8]

Catalog

SLK-S5241

Brand

Selleck

CAS

388082-78-8

DESCRIPTION [388082-78-8]

Overview

MDL	MFCD18904381
Molecular Weight	943.48
Molecular Formula	C43H44ClFN4O11S3
SMILES	S(=O)(=O)(O)C1=CC=C(C)C=C1.N(C=1C2=C(C=CC(=C2)C=3OC(CNCCS(C)(=O)=O)=CC3)N=CN1)C4=CC(Cl)=C(OCC5=CC(F)=CC=C5)C=C4.O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.0599 mL	5.2995 mL	10.5991 mL
5 mM	0.2120 mL	1.0599 mL	2.1198 mL
10 mM	0.1060 mL	0.5300 mL	1.0599 mL
50 mM	0.0212 mL	0.1060 mL	0.2120 mL

Description

Lapatinib ditosylate monohydrate (Lapatinib ditoluenesulfonate monohydrate, Lapatinib tosilate, Lapatinib tosilate hydrate)is a dual inhibitor which interrupts the HER2/neu and epidermal growth factor receptor (EGFR) pathways, used for treatment of solid tumours such as breast and lung cancer.

Targets

ErbB2 ^[1] (Cell-free assay)	EGFR ^[1] (Cell-free assay)	ErbB4 ^[1] (Cell-free assay)
9.2 nM	10.8 nM	367 nM

References

[1] Rusnak DW, et al. Mol Cancer Ther. 2001, 1(2):85-94.

Synonyms

4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-, 4-methylbenzenesulfonate, hydrate (1:2:1)

4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-, bis(4-methylbenzenesulfonate), monohydrate

Lapatinib ditosylate monohydrate