[CAS NO. 54-36-4] Metyrapone

Name: Metyrapone
Brand: Arctom Scientific
SKU: SLK-S5416

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PRODUCTS SPECIFICATIONS [54-36-4]

Distributor

Catalog

SLK-S5416

Brand

Selleck

CAS

54-36-4

DESCRIPTION [54-36-4]

Overview

MDL	MFCD00006397
Molecular Weight	226.27
Molecular Formula	C14H14N2O
SMILES	C(C(C)(C)C=1C=CC=NC1)(=O)C=2C=CC=NC2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Metyrapone (NSC-25265, SU-4885) is an inhibitor of the enzyme that inhibits adrenal steroid synthesis.

Targets

11β-HSD1 ^[1]

30 μM(Ki)

In vitro

Metyrapone is a well known inhibitor of 11β-hydroxylase, a key enzyme involved in the final step of cortisol biosynthesis. At higher concentrations, it also inhibits other steroidogenic enzymes such as cholesterol side chain cleavage enzyme. It is specific for 11β-HSD1 while it has little effect on 11β-HSD2 activity.

In vivo

The administration of metyrapone to man, and animals such as the dog and sheep thus leads to a decrease in circulating levels of cortisol.

References

[1] Sampath-Kumar R, et al. J Steroid Biochem Mol Biol. 1997, 62(2-3):195-9.

Synonyms

1-Propanone, 2-methyl-1,2-di-3-pyridinyl-

1-Propanone, 2-methyl-1,2-di-3-pyridyl-

2-Methyl-1,2-di-3-pyridinyl-1-propanone

1,2-Bis(3-pyridyl)-2-methyl-1-propanone

Mepyrapone

Methapyrapone

Methopirapone

Methopyrapone

Methopyrinine

2-Methyl-1,2-bis(3-pyridyl)-1-propanone

2-Methyl-1,2-di(β-pyridyl)-1-propanone

2-Methyl-1,2-di-3-pyridyl-1-propanone

Metopirone

Metopyrone

Metyrapone

Su 4885

Metopiron

Metyrapon

Methopyrone

Methbipyranone

Metroprione

NSC 25265