[CAS NO. 5578-73-4] Sanguinarine chloride
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:
PRODUCTS SPECIFICATIONS [5578-73-4]
Store
Catalog
SLK-S5452
Brand
Selleck
CAS
5578-73-4
DESCRIPTION [5578-73-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 367.78 |
| Molecular Formula | C20H14NO4.Cl |
| SMILES | C[N+]=1C2=C(C=3C(C1)=C4C(=CC3)OCO4)C=CC=5C2=CC6=C(C5)OCO6.[Cl-] |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7190 mL | 13.5951 mL | 27.1902 mL |
| 5 mM | 0.5438 mL | 2.7190 mL | 5.4380 mL |
| 10 mM | 0.2719 mL | 1.3595 mL | 2.7190 mL |
| 50 mM | - | - | - |
Description
Sanguinarine, a plant alkaloid, is a potent and specific inhibitor. Sanguinarine chloride can stimulate apoptosis via activating the production of . Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.
Targets
| PP2C [1] (Cell-free) |
| 0.68 μM(Ki) |
In vitro
Sanguinarine inhibited PP2C competitively with respect to α-casein (Ki=0.68 μM) and showed selectivity for PP2C as compared with PP1, PP2A, and PP2B in vitro. In vivo, sanguinarine showed cytotoxicity toward human promyelocytic leukemia cell line HL60, with an IC50 value of 0.37 μM, and induced apoptosis through a caspase-3/7-dependent mechanism involving the phosphorylation of p38, a PP2C substrate.
Synonyms
[1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium, 13-methyl-, chloride (1:1)
Sanguinarine, chloride
[1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium, 13-methyl-, chloride
Sanguinarine hydrochloride
13-Methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium chloride
Sanguinarium chloride
Powered by Arctom Copyright © 2026 Arctom. All rights
reserved.